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     Changsha Organic Herb Inc. 

     About this company : Organic Herb Inc. (OHI) has been dedicated to the research and development of innovative nutraceutical ingredients since 1994. Our commitment to science and quality control has earned OHI recognition within the industry as a trusted supplier of ingredients of the highest quality. OHI is the Developer, Manufacturer, Exporter and Primary Supplier of the most remarkable alternative and complementary herbal health products and raw material available today. OHI develops and manufactures superior nutraceutical ingredients. Our trademarked ingredients include: BioSamin™, BioVeratrol™, BioThamin, For more information on our products, please go to our ‘Products’ section.

     Contact : Frank Liu, Manager 
     Headquarters : No. 18, KaiyuanRoad, Xinsha, , Changsha, Hunan, 410100, China
     Phone : 86-731-4060828, Fax : 86-731-4023669 
     Website : Log on to trade instantly , Email : Log on to trade instantly

     Macleaya cordata Extract  Macleaya cordata Extract

Sanguinarine (pseudochelerythrine) from Macleaya cordata Extract

Latin Name: Macleaya cordata (Willd.)

Part Used: Fruit

Active Ingredients: Sanguinarine chelerythrine protopine¦ô-Allocryptopine ¦Â-Allocrytopine Bocconine

Description: Sanguinarine (pseudochelerythrine) is a potent inhibitor of NF-kappaB activation, IkappaBalpha phosphorylation, and degradation.

Macleaya cordata contains several alkaloids including sanguinarine, chelerythrine, protopine, and allocryptopine. Our product, Macleaya cordata extract mainly constains with sanguinarine and chelerythrine. It was been show to be reversible inhibitors of the enzymatic hydrolysis of acetylthiocholine.

It was reported that a study was made of a possible inhibitory action on the enzymatic hydrolysis of acetylthiocholine by human erythrocyte acetylcholinesterase of principal alkaloids isolated from Chelidonium majus L. and Macleaya cordata and microcarpa,and of drugs Ukrain and Sanguirythrine. Among all examined agents berberine, sanguinarine and Sanguirythrine were the strongest inhibitors of this reaction. Judging from the data obtained, sanguinarine and chelerythrine exert similar inhibitory effects on the reaction of enzymatic hydrolysis of acetylthiocholine.

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